Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Sustaining both proteome and genome integrity (GI) requires the integration of a wide range
of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein …

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of
temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully …

Purpose ATP is an essential transmitter/cotransmitter in neuron function and
pathophysiology and has recently emerged as a potential contributor to prolonged seizures …

Traumatic brain injury (TBI) is one of the most frequent causes of death in the young
population. Several clinical trials have unsuccessfully focused on direct neuroprotective …

Insult-provoked transformation of neuronal networks into epileptic ones involves multiple
mechanisms. Intervention studies have identified both dysregulated inflammatory pathways …

The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine
production and neurotransmitter release following brain injury. Levels of the P2X7R are …

Emerging data support roles for microRNA (miRNA) in the pathogenesis of various
neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites …

Epileptogenesis is most commonly associated with neurodegeneration and a bioenergetic
defect attributing to the fact that mitochondrial dysfunction plays a key precursor for neuronal …

Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient
and family history, MRI-imaging and EEG monitoring. There is therefore an unmet clinical …