Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Brown fat is a specialized fat depot that can increase energy expenditure and produce heat.
After the recent discovery of the presence of active brown fat in human adults and novel …

BACKGROUND. The induction of beige adipocytes in sc white adipose tissue (WAT) depots
of humans is postulated to improve glucose and lipid metabolism in obesity. The ability of …

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy
expenditure, has been extensively studied as a potential avenue to combat obesity …

Obesity is one of the most serious public health problems in the 21st century that may lead to
many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current …

Energy balance—that is, the relationship between energy intake and energy expenditure—
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …

Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process
required for maintaining body temperature. BAT is regulated by the sympathetic nervous …

Maintenance of energy homeostasis depends on the highly regulated storage and release
of triacylglycerol primarily in adipose tissue, and excessive storage is a feature of common …

Brain-derived neurotrophic factor (BDNF) is a key regulator of energy balance; however, its
underlying mechanism remains unknown. By analyzing BDNF-expressing neurons in …