Increasing evidence shows that cancer cells can disseminate from early evolved primary
lesions much earlier than the classical metastasis models predicted. Here, we reveal at a …

Complex gene regulatory mechanisms underlie differentiation and reprogramming.
Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA …

Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the
blastocyst, undergo gradual transition marked by changes in gene expression …

Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of
critical roles in mammalian embryonic development. Nodal is essential for the support of the …

R-loops are prevalent in mammalian genomes and involved in many fundamental cellular
processes. Depletion of BRCA2 leads to aberrant R-loop accumulation, contributing to …

ABSTRACT N6-methyladenosine (m6A) is the most prevalent and reversible internal
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …

The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse
embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296 …

The progression from naive through formative to primed in vitro pluripotent stem cell states
recapitulates epiblast development in vivo during the peri-implantation period of mouse …

Abdominal aortic aneurysms (AAAs) are a progressive dilation of the aorta that is
characterized by an initial influx of inflammatory cells followed by a pro‐inflammatory …

Sperm contributes genetic and epigenetic information to the embryo to efficiently support
development. However, the mechanism underlying such developmental competence …