The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

The eukaryotic genome has a hierarchical three-dimensional (3D) organization with
functional implications for DNA replication, DNA repair, and transcriptional regulation. Over …

Bumblebees are a diverse group of globally important pollinators in natural ecosystems and
for agricultural food production. With both eusocial and solitary life-cycle phases, and some …

Immunocytes dynamically reprogram their gene expression profiles during differentiation
and immunoresponse. However, the underlying mechanism remains elusive. Here, we …

Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation.
However, our ability to examine its biological function and role in disease is limited by the …

Background Although spatial organization of compartments and topologically associating
domains at large scale is relatively well studied, the spatial organization of regulatory …

Insight into high-resolution three-dimensional genome organization and its effect on
transcription remains largely elusive in plants. Here, using a long-read ChIA-PET approach …

The genome of a eukaryotic organism is comprised of a supra-molecular complex of
chromatin fibers and intricately folded three-dimensional (3D) structures. Chromosomal …

Background Maize ears and tassels are two separate types of inflorescence which are
initiated by similar developmental processes but gradually develop distinct architectures …

ABSTRACT DNA molecules are highly compacted in the eukaryotic nucleus where distal
regulatory elements reach their targets through three-dimensional chromosomal …