The increased incidence of metabolic diseases (eg, diabetes and obesity) has seriously
affected human health and life safety worldwide. It is of great significance to find effective …

Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress
which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a …

Few medications are available for meeting the increasing disease burden of nonalcoholic
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH) …

Microplastics, which are new types of environmental pollutants, are recently receiving
widespread attention worldwide. Hydrogen sulfide (H 2 S) as the third endogenous gaseous …

Obesity and overweight have increased at an alarming rate in the world during the last three
decades. Obesity is a crucial factor in the development of metabolic abnormalities, including …

Liver pathological changes are as high as 21%-78% in diabetic patients, and treatment
options are lacking. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor that is widely …

Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Liver injury is one of the adverse effects of methotrexate (MTX). Ferulic acid (FA) is an
antioxidant phytochemical that confers hepatoprotective efficacy; however, its effect against …

Sepsis is a systemic inflammatory condition caused by an unbalanced immunological
response to infection, which affects numerous organs, including the intestines …