Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high
predisposition to develop both benign and malignant tumours. Although many …

Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Neurofibromatosis type 1 is a relatively common genetic disease, with a prevalence ranging
between 1/3000 and 1/6000 people worldwide. The disease affects multiple systems with …

Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …

Disclaimer This practice resource is designed primarily as an educational resource for
medical geneticists and other clinicians to help them provide quality medical services …

Background Advances in molecular genetics of sarcoma have enabled the identification of
type-specific aberrations. We aimed to assess the clinical effect of systematic …

MPNST is the sixth most common type of soft-tissue sarcoma, accounting for approximately
5% to 10% of cases. 1–3 Although its exact cellular origins remain unclear, most MPNSTs …

Developing radiosensitizers based on the characteristics of the tumor microenvironment can
improve the effectiveness and overcome the bottleneck of cervical cancer radiotherapy …

Introduction Previous studies in metastatic soft tissue sarcomas (STS) showed that synovial
sarcomas tend to have better survival rates and a higher chemosensitivity than other STS …