Enhancing the activity of drugs by conjugation to organometallic fragments

P Chellan, PJ Sadler - Chemistry–A European Journal, 2020 - Wiley Online Library
Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …

Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple …

M Zaki, S Hairat, ES Aazam - RSC advances, 2019 - pubs.rsc.org
The advent of the clinically approved drug cisplatin started a new era in the design of
metallodrugs for cancer chemotherapy. However, to date, there has not been much success …

Anticancer activity of iridium (III) complexes based on a pyrazole-appended quinoline-based BODIPY

RP Paitandi, S Mukhopadhyay, RS Singh… - Inorganic …, 2017 - ACS Publications
A pyrazole-appended quinoline-based 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene (L1,
BODIPY) has been synthesized and used as a ligand for the preparation of iridium (III) …

Quinine conjugates and quinine analogues as potential antimalarial agents

RA Jones, SS Panda, CD Hall - European journal of medicinal chemistry, 2015 - Elsevier
Malaria is a tropical disease, prevalent in Southeast Asia and Africa, resulting in over half a
million deaths annually; efforts to develop new antimalarial agents are therefore particularly …

Editorial of special issue ruthenium complex: The expanding chemistry of the ruthenium complexes

I Dragutan, V Dragutan, A Demonceau - Molecules, 2015 - mdpi.com
Molecules | Free Full-Text | Editorial of Special Issue Ruthenium Complex: The Expanding
Chemistry of the Ruthenium Complexes Next Article in Journal The Guareschi Pyridine …

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

P Štarha - Coordination Chemistry Reviews, 2021 - Elsevier
The development of multinuclear homometallic biologically active complexes is attractive for
modern bioinorganic chemistry, because this concept offers a multiplication of the …

Anticancer half-sandwich rhodium (III) complexes

K Máliková, L Masaryk, P Štarha - Inorganics, 2021 - mdpi.com
Platinum-based anticancer drugs are most likely the most successful group of bioinorganic
compounds. Their apparent disadvantages have led to the development of anticancer …

Recent advances in the biological investigation of organometallic platinum-group metal (Ir, Ru, Rh, Os, Pd, Pt) complexes as antimalarial agents

M Mbaba, TM Golding, GS Smith - Molecules, 2020 - mdpi.com
In the face of the recent pandemic and emergence of infectious diseases of viral origin,
research on parasitic diseases such as malaria continues to remain critical and innovative …

Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs

A Fulmali, SS Bharate - Drug Development Research, 2022 - Wiley Online Library
The salification and prodrug approaches modulate the physicochemical properties and
absorption, distribution, metabolism, excretion, and toxicity parameters of drugs and lead …