Molecular mechanisms and physiological changes behind benign tracheal and subglottic stenosis in adults

A Marchioni, R Tonelli, A Andreani… - International Journal of …, 2022 - mdpi.com
Laryngotracheal stenosis (LTS) is a complex and heterogeneous disease whose
pathogenesis remains unclear. LTS is considered to be the result of aberrant wound-healing …

An updated review of subglottic stenosis: etiology, evaluation, and management

LJ Pasick, MM Anis, DE Rosow - Current pulmonology reports, 2022 - Springer
Abstract Purpose of Review To assimilate the newly published literature regarding subglottic
stenosis (SGS), including basic science and translational research on mechanisms of …

Laryngotracheal stenosis: Mechanistic review

DJ Carpenter, OA Hamdi, AM Finberg… - Head & Neck, 2022 - Wiley Online Library
Background The purpose of this review article is to summarize the existing literature
surrounding wound healing mechanisms in laryngotracheal stenosis. Methods A review of …

[HTML][HTML] RNA sequencing of idiopathic subglottic stenosis tissues uncovers putative profibrotic mechanisms and identifies a prognostic biomarker

C Zhang, S Wang, MC Moura, SY Eunhee… - The American Journal of …, 2022 - Elsevier
Idiopathic subglottic stenosis (iSGS) is a localized airway disease that almost exclusively
affects females. Understanding the molecular mechanisms involved may provide insights …

M2 macrophages promote collagen expression and synthesis in laryngotracheal stenosis fibroblasts

K Motz, I Lina, MK Murphy, V Drake, R Davis… - The …, 2021 - Wiley Online Library
Objective Macrophages exhibit distinct phenotypes and are dysregulated in a model of
iatrogenic laryngotracheal stenosis (iLTS). Increased populations of alternatively activated …

Pathologic fibroblasts in idiopathic subglottic stenosis amplify local inflammatory signals

RJ Morrison, NG Katsantonis, KM Motz… - … –Head and Neck …, 2019 - journals.sagepub.com
Objective To characterize the phenotype and function of fibroblasts derived from airway scar
in idiopathic subglottic stenosis (iSGS) and to explore scar fibroblast response to interleukin …

Antibiofilm Activity of Human Milk Oligosaccharides against Multidrug Resistant and Susceptible Isolates of Acinetobacter baumannii

SK Spicer, RE Moore, J Lu, MA Guevara… - ACS infectious …, 2021 - ACS Publications
Acinetobacter baumannii is a serious threat to human health, per the Centers for Disease
Control and Prevention's latest threat assessment. A. baumannii is a Gram-negative …

[HTML][HTML] Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen

A Gelbard, MH Shilts, B Strickland, K Motz… - Research …, 2023 - ncbi.nlm.nih.gov
Background Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal
airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory …

Impact of adjuvant medical therapies on surgical outcomes in idiopathic subglottic stenosis

MR Hoffman, A Patro, LC Huang, SC Chen… - The …, 2021 - Wiley Online Library
Objectives/Hypothesis Adjuvant medications including proton pump inhibitors (PPI),
antibiotics (trimethoprim/sulfamethoxazole [TMP‐SMX]), and inhaled corticosteroids (ICS) …

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

JM Townsend, LM Ott, JR Salash, KM Fung… - … Engineering Part A, 2018 - liebertpub.com
Tracheal stenosis caused by congenital anomalies, tumors, trauma, or intubation-related
damage can cause severe breathing issues, diminishing the quality of life, and potentially …