The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

The optimal timing of valve surgery remains controversial. Biomarkers can be serially
monitored and are objective laboratory measurements. Plasma B-type natriuretic peptide …

Background Aortic stenosis (AS) and transthyretin cardiac amyloidosis (TTR-CA) are both
frequent in elderly. The combination of these two diseases has never been investigated …

Diabetic cardiomyopathy (DCM) is a dreadful complication of diabetes responsible for 80%
mortality in diabetic patients, but unfortunately its pharmacotherapy is still incomplete. Rutin …

Cardiomyopathies and valvular heart diseases are typically considered distinct diagnostic
categories with dedicated guidelines for their management. However, the interplay between …

Calcified aortic valve disease (CAVD) was previously regarded as a passive process
associated with valve degeneration and calcium deposition. However, recent studies have …

Background: In an intervention study where 221 healthy elderly persons received selenium
and coenzyme Q10 as a dietary supplement, and 222 received placebo for 4 years we …

Introduction: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular
(LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and …

Extracellular matrix protein turnover may play an important role in left atrial (LA) remodelling.
The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue …

Aortic valve sclerosis is a highly prevalent, poorly characterized asymptomatic manifestation
of calcific aortic valve disease and may represent a therapeutic target for disease mitigation …