Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses

Y Yang, F Li, L Du - Journal of Nanobiotechnology, 2024 - Springer
Nanobodies, single-domain antibodies derived from variable domain of camelid or shark
heavy-chain antibodies, have unique properties with small size, strong binding affinity, easy …

Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2

O Cabanillas-Bernal, BJ Valdovinos-Navarro… - Frontiers in …, 2023 - frontiersin.org
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) generated a joint global effort to develop vaccines and other treatments that could …

VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica)

H Takeda, T Ozawa, H Zenke, Y Ohnuki… - … in Bioengineering and …, 2023 - frontiersin.org
The VNAR (Variable New Antigen Receptor) is the smallest single-domain antibody derived
from the variable domain of IgNAR of cartilaginous fishes. Despite its biomedical and …

Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)

T Nakada-Masuta, H Takeda, K Uchida - Marine Drugs, 2023 - mdpi.com
Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic
applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has …

Exploring shark VNAR antibody against infectious diseases using phage display technology

HT Lim, BH Kok, CY Leow, CH Leow - Fish & Shellfish Immunology, 2023 - Elsevier
Antibody with high affinity and specificity to antigen has widely used as a tool to combat
various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) …

Novel Approach for Obtaining VNAR with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica)

T Nakada-Masuta, H Takeda, K Uchida - 2023 - preprints.org
Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic
applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has …

[引用][C] 단일도메인항체의특성및활용방안

나정현, 김우성 - BT NEWS, 2023 - dbpia.co.kr
인류 문명이 발달함에 따라 코로나바이러스 감염증-19 (COVID-19) 와 같은 새로운신규 감염성
질환 또한 끊임없이 등장하고 있다. 이에 따라 신규 감염성 질환을 치료하거나 진단할 수 있는 …