Biological systems are composed of heterogeneous populations of cells that
intercommunicate to form a functional living tissue. Biological function varies greatly across …

In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

Matrix-assisted laser desorption–ionization mass spectrometry imaging in transmission-
mode geometry (t-MALDI–MSI) can provide molecular information with a pixel size of 1 µm …

We report an atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI)
mass spectrometry imaging (MSI) setup with a lateral resolution of 1.4 μm, a mass resolution …

The advent of glass-based microfluidic devices further revolutionized in microfluidic
technology due to the several advantageous properties in terms of photonics, electronics …

Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of
biological tissues at cellular resolutions. New developments and technologies are essential …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …

Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …