An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

X Liu, Z Zhang, Y Song, H Xie, M Dong - Frontiers in endocrinology, 2023 - frontiersin.org
Overweight and obesity have become a world-wide problem. However, effective intervention
approaches are limited. Brown adipose tissue, which helps maintain body temperature and …

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Z Li, Z Gao, T Sun, S Zhang, S Yang, M Zheng… - Frontiers in …, 2023 - frontiersin.org
Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted
protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier …

Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2024 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

The effect of exercise training on irisin secretion in patients with type 2 diabetes: a systematic review

M Vecchiato, E Zanardo, F Battista, G Quinto… - Journal of clinical …, 2022 - mdpi.com
Introduction: Irisin is a myokine considered to be a potential mediator of exercise-induced
energy metabolism and its secretion is known to promote the browning of beige fat cells in …

New discovered adipokines associated with the pathogenesis of obesity and type 2 diabetes

JX Cheng, K Yu - … , metabolic syndrome and obesity: targets and …, 2022 - Taylor & Francis
Obesity is defined as abnormal or excessive accumulation of adipose tissue, closely
associated with the increased risk of various comorbidities, especially type 2 diabetes …

Attenuation of brown adipocyte whitening in high‐fat diet‐induced obese rats: Effects of melatonin and β‐hydroxybutyrate on Cidea, Fsp27 and MT1 expression

MH Maleki, S Khakshournia… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim To investigate the effects of β‐hydroxybutyrate (BHB) and melatonin on brown adipose
tissue (BAT) plasticity in rats fed a high‐fat diet (HFD). Methods We employed a 7‐week …

Physical activity and batokines

GU Ortiz, EC de Freitas - American Journal of Physiology …, 2023 - journals.physiology.org
Brown and beige adipose tissue share similar functionality, being both tissues specialized in
producing heat through nonshivering thermogenesis and also playing endocrine roles …

Sweet swell of burning fat: emerging role of high-density lipoprotein in energy homeostasis

A Kontush, M Martin, F Brites - Current Opinion in Lipidology, 2023 - journals.lww.com
Sweet swell of burning fat: emerging role of high-density li... : Current Opinion in Lipidology
Sweet swell of burning fat: emerging role of high-density lipoprotein in energy homeostasis …

Molecular insights of exercise therapy in disease prevention and treatment

D Walzik, TY Wences Chirino, P Zimmer… - Signal Transduction and …, 2024 - nature.com
Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the
prevention and treatment of various diseases, the underlying biological mechanisms have …

Mouse models for metabolic health research: molecular mechanism of exercise effects on health improvement through adipose tissue remodelling

HJ Kim, YJ Kim, JK Seong - The Journal of Physiology, 2025 - Wiley Online Library
Exercise provides health benefits to multiple metabolic tissues through complex biological
pathways and interactions between organs. However, investigating these complex …