Morphine (MPH) is widely used for pain management; however, long-term MPH therapy
results in antinociceptive tolerance and physical dependence, limiting its clinical use …

We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine
ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of …

The molecular mechanisms underlying the acquisition of addiction/dependence on
morphine may result from the ability of the opioid to diminish the transport of L-cysteine into …

We have reported that D, L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are
effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going …

Acetaminophen (paracetamol) is one of the most popular analgesics for the management of
fever and pain but few reports have investigated its antidepressant-like effect. Moreover, the …

At present morphine is widely used for the management of acute pain and moderate to
severe pain. Although numerous studies have demonstrated that morphine has …

Background: Opioids are essential for pain treatment, but their long-term usage results in
tolerance. Naringenin, a natural flavonoid found in fruit, inhibits the enzyme that causes …

It has been shown that carbamazepine, an anticonvulsant drug, has antidepressant effects.
Moreover, the involvement of opioid system has been shown in the pathophysiology of …

Objective This study aimed to investigate the antidepressant effect of simvastatin in the
hydrocortisone model of depression. Background Depression is considered the most …