Gold (III) complexes for antitumor applications: an overview

B Bertrand, MRM Williams… - Chemistry–A European …, 2018 - Wiley Online Library
Gold (III) complexes have emerged as a versatile and effective class of metal‐based
anticancer agents. The development of various types of ligands capable of stabilizing the …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

Organometallic gold (III) complexes similar to tetrahydroisoquinoline induce ER-stress-mediated apoptosis and pro-death autophagy in A549 cancer cells

KB Huang, FY Wang, XM Tang, HW Feng… - Journal of medicinal …, 2018 - ACS Publications
Agents inducing both apoptosis and autophagic death can be effective chemotherapeutic
drugs. In our present work, we synthesized two organometallic gold (III) complexes …

Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for …

Y Luo, B Cao, M Zhong, M Liu, X Xiong… - Angewandte …, 2022 - Wiley Online Library
Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in
combating cancers but suffers from low activity under hypoxia, whereas photoactivated …

Anticancer gold (III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition

JH Kim, S Ofori, S Parkin, H Vekaria, PG Sullivan… - Chemical …, 2021 - pubs.rsc.org
Expanding the chemical diversity of metal complexes provides a robust platform to generate
functional bioactive reagents. To access an excellent repository of metal-based compounds …

Cancer cell-selective modulation of mitochondrial respiration and metabolism by potent organogold (iii) dithiocarbamates

RT Mertens, S Parkin, SG Awuah - Chemical Science, 2020 - pubs.rsc.org
Metabolic reprogramming is a key cancer hallmark that has led to the therapeutic targeting
of glycolysis. However, agents that target dysfunctional mitochondrial respiration for targeted …

Strong in vitro and vivo cytotoxicity of novel organoplatinum (II) complexes with quinoline-coumarin derivatives

QP Qin, ZF Wang, XL Huang, MX Tan, BQ Zou… - European Journal of …, 2019 - Elsevier
A series of novel organoplatinum (II) complexes,[Pt II (QC1)(H-QC1) Cl](Pt1),[Pt II (QC2)(H-
QC2) Cl](Pt2),[Pt II (QC3)(H-QC3) Cl](Pt3),[Pt II (QC4)(H-QC4) Cl]⋅ CH 3 OH (Pt4),[Pt II …

Design, synthesis, characterization, and antiproliferative activity of organoplatinum compounds bearing a 1, 2, 3-triazole ring

K Singh, A Gangrade, A Jana, BB Mandal, N Das - ACS Omega, 2019 - ACS Publications
The syntheses, characterizations, and biological activities of three organoplatinum
compounds, each containing a triazole ring, are discussed. These organometallic …

Self‐Assembled Metal Complexes in Biomedical Research

W Wang, Y Xu, Y Tang, Q Li - Advanced Materials, 2024 - Wiley Online Library
Cisplatin is widely used in clinical cancer treatment; however, its application is often
hindered by severe side effects, particularly inherent or acquired resistance of target cells …