The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
Modelling metabolic diseases and drug response using stem cells and organoids
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …
major threat to health in the modern world, but efforts to understand the underlying …
The endocrine role of brown adipose tissue: An update on actors and actions
In recent years, brown adipose tissue (BAT) has been recognized not only as a main site of
non-shivering thermogenesis in mammals, but also as an endocrine organ. BAT secretes a …
non-shivering thermogenesis in mammals, but also as an endocrine organ. BAT secretes a …
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis
Adaptive thermogenesis by brown adipose tissue (BAT) dissipates calories as heat, making
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …
it an attractive anti-obesity target. Yet how BAT contributes to circulating metabolite …
Creatine promotes cancer metastasis through activation of Smad2/3
L Zhang, Z Zhu, H Yan, W Wang, Z Wu, F Zhang… - Cell metabolism, 2021 - cell.com
As one of the most popular nutrient supplements, creatine has been highly used to increase
muscle mass and improve exercise performance. Here, we report an adverse effect of …
muscle mass and improve exercise performance. Here, we report an adverse effect of …
[HTML][HTML] Advancing targeted protein degradation for metabolic diseases therapy
QQ Zhou, HT Xiao, F Yang, YD Wang, P Li… - Pharmacological …, 2023 - Elsevier
The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …
chemical drugs and biological agents, especially inhibitors, have become the mainstream …
In vitro and ex vivo models of adipocytes
Adipocytes are specialized cells with pleiotropic roles in physiology and pathology. Several
types of fat cells with distinct metabolic properties coexist in various anatomically defined fat …
types of fat cells with distinct metabolic properties coexist in various anatomically defined fat …
Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine
R Zheng, L Zhang, R Parvin, L Su, J Chi… - Advanced …, 2023 - Wiley Online Library
Translational medicine aims to improve human health by exploring potential treatment
methods developed during basic scientific research and applying them to the treatment of …
methods developed during basic scientific research and applying them to the treatment of …
Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue
Thermogenic adipose tissue, consisting of brown and beige fat, regulates nutrient utilization
and energy metabolism. Human brown fat is relatively scarce and decreases with obesity …
and energy metabolism. Human brown fat is relatively scarce and decreases with obesity …
A natural anti-obesity reagent derived from sea buckthorn polysaccharides: Structure characterization and anti-obesity evaluation in vivo
Z Ma, Q Sun, L Chang, J Peng, M Zhang, X Ding… - Food Chemistry, 2022 - Elsevier
Sea buckthorn polysaccharide (SBP) has received increasing attention for its various
bioactive functions. In this study, a novel polysaccharide SBP-1 was initially separated from …
bioactive functions. In this study, a novel polysaccharide SBP-1 was initially separated from …