Role of lysosomes in physiological activities, diseases, and therapy

Z Zhang, P Yue, T Lu, Y Wang, Y Wei, X Wei - Journal of hematology & …, 2021 - Springer
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics

X Zhang, S Huang, J Guo, L Zhou… - International …, 2016 - spandidos-publications.com
The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis,
apoptosis and invasion are greatly influenced by the surrounding microenvironment. The …

Novel immunotherapy against several tumors, such as lung cancer, including nsclc

T Weinschenk, S Walter, J Fritsche, S Colette, H Singh - 2015 - Google Patents
The present invention relates to peptides, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the …

Dual tumor‐suppressors miR‐139‐5p and miR‐139‐3p targeting matrix metalloprotease 11 in bladder cancer

M Yonemori, N Seki, H Yoshino, R Matsushita… - Cancer …, 2016 - Wiley Online Library
Our recent study of the micro RNA (mi RNA) expression signature of bladder cancer (BC) by
deep‐sequencing revealed that two mi RNA, micro RNA‐139‐5p/micro RNA‐139‐3p were …

Expression of CD147 and matrix metalloproteinase-11 in colorectal cancer and their relationship to clinicopathological features

X Tian, C Ye, Y Yang, X Guan, B Dong, M Zhao… - Journal of Translational …, 2015 - Springer
Background This study aimed to investigate the expression of CD147 and MMP-11 in
human colorectal cancer (CRC) and to evaluate their clinical significance. Methods Real …

Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray

L Yang, J Wang, J Li, H Zhang, S Guo, M Yan… - Molecular & Cellular …, 2016 - ASBMB
We aimed to globally discover serum biomarkers for diagnosis of gastric cancer (GC). GC
serum autoantibodies were discovered and validated using serum samples from …

The multifaceted role of the lysosomal protease cathepsins in kidney disease

P Cocchiaro, V De Pasquale, R Della Morte… - Frontiers in Cell and …, 2017 - frontiersin.org
Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire
population. Kidney disease encompasses acute (short-lasting episode) and chronic …

[HTML][HTML] The paradoxical role of matrix metalloproteinase-11 in cancer

B Ma, R Ran, HY Liao, HH Zhang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The microenvironment surrounding the tumor affects biological processes, such as cell
proliferation, angiogenesis, apoptosis, and invasion. Therefore, the ability to change these …

Expression of TIMPs and MMPs in ovarian tumors, ascites, ascites-derived cells, and cancer cell lines: characteristic modulatory response before and after …

RM Escalona, G Kannourakis, JK Findlay… - Frontiers in …, 2022 - frontiersin.org
Background The tissue inhibitors of metalloproteinase (TIMPs) and their associated
metalloproteinase (MMPs) are essential regulators of tissue homeostasis and are essential …

Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer

SM Wilting, J de Wilde, CJLM Meijer… - Genes …, 2008 - Wiley Online Library
For a better understanding of the consequences of recurrent chromosomal alterations in
cervical carcinomas, we integrated genome‐wide chromosomal and transcriptional profiles …