Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory

T Rückert, CA Lareau, MF Mashreghi, LS Ludwig… - Nature …, 2022 - nature.com
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

L Zhang, Y Jiang, J He, J Chen, R Qi, L Yuan… - Nature …, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …

Natural killer cell therapies

E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

S Sivori, P Vacca, G Del Zotto, E Munari… - Cellular & molecular …, 2019 - nature.com
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …

Exploiting innate immunity for cancer immunotherapy

M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Natural killer cells: from innate to adaptive features

AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

Human immunology and immunotherapy: main achievements and challenges

J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …