Differentiated Caco-2 cell models in food-intestine interaction study: Current applications and future trends

X Ding, X Hu, Y Chen, J Xie, M Ying, Y Wang… - Trends in Food Science & …, 2021 - Elsevier
Background Food-intestine interaction study has always been a hot topic in food science
and nutrition due to diverse physiological functions of intestine. Compared to expensive …

Trends in advanced oral drug delivery system for curcumin: A systematic review

S Pan-On, P Dilokthornsakul… - Journal of Controlled …, 2022 - Elsevier
Although curcumin is globally recognized for its health benefits, its clinical application has
been restricted by its poor aqueous solubility and stability. To overcome these limitations …

[HTML][HTML] Synergistic effects of plant derivatives and conventional chemotherapeutic agents: an update on the cancer perspective

R Pezzani, B Salehi, S Vitalini, M Iriti, FA Zuñiga… - Medicina, 2019 - mdpi.com
Synergy is a process in which some substances cooperate to reach a combined effect that is
greater than the sum of their separate effects. It can be considered a natural “straight” …

[HTML][HTML] Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines

E Gheytanchi, M Naseri, F Karimi-Busheri… - Cancer cell …, 2021 - Springer
Background Relapse and metastasis in colorectal cancer (CRC) are often attributed to
cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug …

Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery

S Nasirizadeh, B Malaekeh-Nikouei - Journal of Drug Delivery Science and …, 2020 - Elsevier
Most cancer disease can be treated by the parenteral anticancer delivery method. The
intravenous route takes the wholly bioavailable, accurate dose of the drug immediately to …

Critical evaluation of causality assessment of herb–drug interactions in patients

C Awortwe, M Makiwane, H Reuter… - British journal of …, 2018 - Wiley Online Library
The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to
herb–drug interactions (HDI) in patients taking herbs and prescribed medications based on …

Interactions between CYP3A4 and dietary polyphenols

L Basheer, Z Kerem - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad
spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as …

Epigallocatechin gallate as a nutraceutical to potentially target the metabolic syndrome: Novel insights into therapeutic effects beyond its antioxidant and anti …

Y Ntamo, B Jack, K Ziqubu… - Critical Reviews in …, 2024 - Taylor & Francis
Epigallocatechin gallate (EGCG) is one of the most abundant and powerful flavonoids
contained in green tea. Because of the global increase in green tea consumption, there has …

Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

JG In, J Foulke-Abel, MK Estes, NC Zachos… - Nature reviews …, 2016 - nature.com
The development of indefinitely propagating human'mini-guts' has led to a rapid advance in
gastrointestinal research related to transport physiology, developmental biology …

Transport, metabolism and remedial potential of functional food extracts (FFEs) in Caco-2 cells monolayer: A review

M Iftikhar, A Iftikhar, H Zhang, L Gong… - Food Research …, 2020 - Elsevier
Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and
transport mechanism of functional foods and drugs across the intestinal epithelium in order …