Vaccination serves as a cornerstone of global health. Successful prevention of infection or
disease by vaccines is achieved through elicitation of pathogen-specific antibodies and long …

Trogocytosis modulates immune responses, with still unclear underlying molecular
mechanisms. Using leukemia mouse models, we found that lymphocytes perform …

Cancer cells elude anti-tumour immunity through multiple mechanisms, including
upregulated expression of ligands for inhibitory immune checkpoint receptors,. Phagocytosis …

Immune modulatory therapies are widely believed to represent potential therapeutic
strategies for chronic hepatitis B infection (CHB). Among the cellular targets for immune …

CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …

To investigate whether IL‐6 signaling affects the susceptibility of castration‐resistant
prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines …

Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by
macrophages and is a promising avenue in anti-cancer therapy. Productive phagocytosis is …

Cancer cells often overexpress CD47, which triggers the inhibitory receptor SIRPα
expressed on macrophages, to elude phagocytosis and antitumor immunity …

Invariant natural killer T cells (iNKT cells) develop through an incompletely understood
process that requires positive selection by CD4+ CD8+ double-positive thymocytes and …

The original discovery of NK cells approximately 40 yr ago was based on their unique
capability to kill tumor cells without prior sensitization or priming, a process named natural …