Electrogenesis in the heart begins in the sinoatrial node and proceeds down the conduction
system to originate the heartbeat. Conduction system disorders lead to slow heart rates that …

Although sinus node dysfunction (SND) and atrial arrhythmias frequently coexist and
interact, the putative mechanism linking the 2 remain unclear. Although SND is …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

Abstract This Committee Report provides methodological, interpretive, and reporting
guidance for researchers who use measures of heart rate (HR) and heart rate variability …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Key points We constructed a comprehensive mathematical model of the spontaneous
electrical activity of a human sinoatrial node (SAN) pacemaker cell, starting from the recent …

The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the
primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that …

The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND)
is common, but until recently the pathophysiology was incompletely understood. It was …

Sick sinus syndrome remains a highly relevant clinical entity, being responsible for the
implantation of the majority of electronic pacemakers worldwide. It is an infinitely more …

Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the
ubiquitously expressed cardiac voltage-gated L-type Cav1. 2 Ca2+ channel isoform …