Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a curable airborne
disease currently treated using a drug regimen consisting of four drugs. Global TB control …

Introduction In recent years, the advent of multidrug-resistant tuberculosis (MDR-TB), the
extensively-resistant TB (XDR-TB), and the total drug-resistant-TB (TDR-TB) have led the …

Macozinone, a piperazine-benzothiazinone PBTZ169, is currently undergoing Phase 1/2
clinical studies for the treatment of tuberculosis (TB). In this review we summarize the key …

Mycobacterium tuberculosis (Mtb) has an impermeable cell wall which gives it an inherent
ability to resist many antibiotics. DprE1, an essential enzyme in Mtb cell wall synthesis, has …

Despite decades of research in drug development against TB, it is still the leading cause of
death due to infectious diseases. The long treatment duration, patient noncompliance …

Tuberculosis, and especially multidrug-resistant tuberculosis (MDR-TB), is a major global
health threat which emphasizes the need to develop new agents to improve and shorten …

Tuberculosis remains the second deadliest infectious disease in humans and a public
health threat due to the emergence of multidrug-resistant (MDR-TB) and extensively drug …

Global health is still seriously threatened by tuberculosis (TB), especially considering the
increasing incidence of strains of the disease that are extensively drug-resistant (XDR) and …

Pseudomonas aeruginosa (P. aeruginosa) is a highly infectious and antibiotic-resistant
bacterium, which causes acute and chronic nosocomial infections. P. aeruginosa exhibits …

Tuberculosis is the leading bacterial killer worldwide. 8-Nitro-4H-benzo [e][1, 3] thiazin-4-
ones are a potent class of antitubercular agents with a new mechanism of action. BTZ043 …