[HTML][HTML] Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AM Posadino, R Giordo, G Pintus… - Biomedicine & …, 2023 - Elsevier
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has
been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial …

[HTML][HTML] Oxygen metabolism abnormality and Alzheimer's disease: An update

G Liu, C Yang, X Wang, X Chen, Y Wang, W Le - Redox Biology, 2023 - Elsevier
Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's
disease (AD) via several mechanisms, including hypoxia, oxidative stress, and …

[HTML][HTML] Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1/2/CREB/BCL-2 signaling pathway in vitro and in vivo

T Peng, S Li, L Liu, C Yang, M Farhan… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Ischemic stroke is characterized by the presence of both brain ischemic and reperfusion-
induced injuries in the brain, leading to neuronal dysfunction and death. Artemisinin, an FDA …

[HTML][HTML] Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway

M Ding, R Shi, F Fu, M Li, D De, Y Du, Z Li - Journal of Advanced Research, 2023 - Elsevier
Introduction The anti-cancer medication doxorubicin (Dox) is largely restricted in clinical
usage due to its significant cardiotoxicity. The only medication approved by the FDA for Dox …

[HTML][HTML] Artemisinin attenuates amyloid-induced brain inflammation and memory impairments by modulating TLR4/NF-κB signaling

X Zhao, X Huang, C Yang, Y Jiang, W Zhou… - International journal of …, 2022 - mdpi.com
The abnormal immune response is an early change in the pathogenesis of Alzheimer's
disease (AD). Microglial activation is a crucial regulator of the immune response, which …

[HTML][HTML] Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress

M Chen, Y Chen, W Zhu, X Yan, J Xiao, P Zhang… - Biomedicine & …, 2023 - Elsevier
Diabetic nephropathy (DN) is one of the serious complications of diabetes mellitus, primarily
arising from type 2 diabetes (T2DM), and can progress to chronic kidney disease (CKD) and …

Current progress on neuroprotection induced by Artemisia, Ginseng, Astragalus, and Ginkgo traditional Chinese medicines for the therapy of Alzheimer's disease

Q Li, L Rubin, M Silva, S Li, C Yang… - Oxidative Medicine …, 2022 - Wiley Online Library
Aging is associated with the occurrence of diverse degenerative changes in various tissues
and organs and with an increased incidence of neurological disorders, especially …

[HTML][HTML] Protective Effects and Mechanisms of Pectolinarin against H2O2-Induced Oxidative Stress in SH-SY5Y Neuronal Cells

QQ Pang, JH Kim, HY Kim, JH Kim, EJ Cho - Molecules, 2023 - mdpi.com
This study aims to investigate the protective effects and mechanisms of pectolinarin against
oxidative stress-induced cell damage in SH-SY5Y cells. Neurodegenerative diseases—such …

[HTML][HTML] Artemisinin confers neuroprotection against 6-OHDA-induced neuronal injury in vitro and in vivo through activation of the ERK1/2 pathway

Q Li, S Li, J Fang, C Yang, X Zhao, Q Wang, W Zhou… - Molecules, 2023 - mdpi.com
Parkinson's disease (PD) is an age-related, progressive neurodegenerative disease
characterized by the gradual and massive loss of dopaminergic neurons in the substantia …

[HTML][HTML] Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF …

W Tian, S Heo, DW Kim, IS Kim, D Ahn, HJ Tae… - International Journal of …, 2021 - mdpi.com
Free radical generation and oxidative stress push forward an immense influence on the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Parkinson's …