The mystery of membrane organization: composition, regulation and roles of lipid rafts

E Sezgin, I Levental, S Mayor, C Eggeling - Nature reviews Molecular …, 2017 - nature.com
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

The lipid basis of cell death and autophagy

Z Lin, F Long, R Kang, DJ Klionsky, M Yang, D Tang - Autophagy, 2024 - Taylor & Francis
Triglycerides, phospholipids, and cholesterol are prominent lipid types that serve diverse
biological functions. These lipids act as vital structural components of cell membranes …

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

B Mathew, S Ravindran, X Liu, L Torres… - Biomaterials, 2019 - Elsevier
Retinal ischemia is a major cause of vision loss and impairment and a common underlying
mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central …

Structural basis for abscisic acid efflux mediated by ABCG25 in Arabidopsis thaliana

W Ying, L Liao, H Wei, Y Gao, X Liu, L Sun - Nature Plants, 2023 - nature.com
Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of
plant growth and development. The cellular level of ABA is critical to its signalling and is …

The challenges of oral drug delivery via nanocarriers

J Reinholz, K Landfester, V Mailänder - Drug delivery, 2018 - Taylor & Francis
The oral application of pharmaceuticals is unarguably the most convenient method of
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …

Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo

P Zhupanyn, A Ewe, T Büch, A Malek… - Journal of Controlled …, 2020 - Elsevier
Extracellular vesicles (ECVs) are secreted cell-derived membrane particles involved in
intercellular signaling and cell-cell communication. By transporting various bio …

Dysregulation of cholesterol homeostasis in human lung cancer tissue and tumour-associated macrophages

J Hoppstädter, A Dembek, M Höring, HS Schymik… - …, 2021 - thelancet.com
Background Based on reports on elevated cholesterol levels in cancer cells, strategies to
lower cholesterol synthesis have been suggested as an antitumour strategy. However …

Secretion of tau via an unconventional non-vesicular mechanism

M Merezhko, CA Brunello, X Yan, H Vihinen, E Jokitalo… - Cell reports, 2018 - cell.com
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

New insights into targeting membrane lipids for cancer therapy

G Preta - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Modulation of membrane lipid composition and organization is currently developing as an
effective therapeutic strategy against a wide range of diseases, including cancer. This field …

Single-vesicle assays using liposomes and cell-derived vesicles: from modeling complex membrane processes to synthetic biology and biomedical applications

H Pick, AC Alves, H Vogel - Chemical reviews, 2018 - ACS Publications
The plasma membrane is of central importance for defining the closed volume of cells in
contradistinction to the extracellular environment. The plasma membrane not only serves as …