Identification of the key ingredients and essential processes required to achieve perfect
tissue regeneration in humans has so far remained elusive. Injury in vertebrates induces an …

Significance: Skin scarring poses a major biomedical burden for hundreds of millions of
patients annually. However, this burden could be mitigated by therapies that promote wound …

Landmark‐based geometric morphometrics has emerged as an essential discipline for the
quantitative analysis of size and shape in ecology and evolution. With the ever‐increasing …

Whereas amphibians regenerate lost appendages spontaneously, mammals generally form
scars over the injury site through the process of wound repair. The MRL mouse strain is an …

In this chapter we will review both the rationale and experimental design for using
Heterogeneous Stock (HS) populations for fine-mapping of complex traits in mice and rats …

In adult mammals, skin wounds typically heal by scarring rather than through regeneration.
In contrast," super-healer" Murphy Roths Large (MRL) mice have the unusual ability to …

Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute
to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits …

Obesity is generally protective against osteoporosis and bone fracture. However, recent
studies indicate that the influence of obesity on the skeleton is complex and can be …

The discovery that the Murphy Roths Large (MRL) mouse strain is a fully competent,
epimorphic tissue regenerator, proved that the machinery of regeneration was preserved …

Objective: The wound healing response may be viewed as partially overlapping sets of two
physiological processes, regeneration and wound repair with the former overrepresented in …