Resistance to Therapies for Infection by Plasmodium vivax

JK Baird - Clinical microbiology reviews, 2009 - Am Soc Microbiol
The gravity of the threat posed by vivax malaria to public health has been poorly
appreciated. The widely held misperception of Plasmodium vivax as being relatively …

Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia

E Tjitra, NM Anstey, P Sugiarto, N Warikar… - PLoS …, 2008 - journals.plos.org
Background Multidrug-resistant Plasmodium vivax (Pv) is widespread in eastern Indonesia,
and emerging elsewhere in Asia-Pacific and South America, but is generally regarded as a …

Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea

B Genton, V D'Acremont, L Rare, K Baea… - PLoS …, 2008 - journals.plos.org
Background Severe malaria (SM) is classically associated with Plasmodium falciparum
infection. Little information is available on the contribution of P. vivax to severe disease …

A trial of combination antimalarial therapies in children from Papua New Guinea

HA Karunajeewa, I Mueller, M Senn, E Lin… - … England Journal of …, 2008 - Mass Medical Soc
Background Malaria control is difficult where there is intense year-round transmission of
multiple plasmodium species, such as in Papua New Guinea. Methods Between April 2005 …

Amplification of pvmdr1 Associated with Multidrug-Resistant Plasmodium vivax

R Suwanarusk, M Chavchich, B Russell… - The Journal of …, 2008 - academic.oup.com
Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast
Asia. Methods. In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax …

Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds

AU Krettli - Expert Opinion on Drug Discovery, 2009 - Taylor & Francis
Background: Malaria is the most important parasitic disease and its control depends on
specific chemotherapy, now complicated by Plasmodium falciparum that has become …

Plasmodium vivax Resistance to Chloroquine in Madagascar: Clinical Efficacy and Polymorphisms in pvmdr1 and pvcrt-o Genes

C Barnadas, A Ratsimbasoa, M Tichit… - Antimicrobial agents …, 2008 - Am Soc Microbiol
No data were available concerning Plasmodium vivax resistance to chloroquine (CQ) in
Madagascar. We investigated the therapeutic efficacy of CQ in P. vivax malaria, the …

Evaluation of Plasmodium vivax Genotyping Markers for Molecular Monitoring in Clinical Trials

C Koepfli, I Mueller, J Marfurt, M Goroti… - The Journal of …, 2009 - academic.oup.com
Background Many antimalarial interventions are accompanied by molecular monitoring of
parasite infections, and a number of molecular typing techniques based on different …

Expression Levels of pvcrt-o and pvmdr-1 Are Associated with Chloroquine Resistance and Severe Plasmodium vivax Malaria in Patients of the Brazilian Amazon

GC Melo, WM Monteiro, AM Siqueira, SR Silva… - PloS one, 2014 - journals.plos.org
Molecular markers associated with the increase of chloroquine resistance and disease
severity in Plasmodium vivax are needed. The objective of this study was to evaluate the …

Molecular Markers of In Vivo Plasmodium vivax Resistance to Amodiaquine Plus Sulfadoxine-Pyrimethamine: Mutations in pvdhfr and pvmdr1

J Marfurt, F de Monbrison, S Brega… - The Journal of …, 2008 - academic.oup.com
Background. Molecular markers for sulfadoxine-pyrimethamine (SP) resistance in
Plasmodium vivax have been reported. However, data on the molecular correlates involved …