Exosomal long non-coding RNAs in lung diseases

C Poulet, MS Njock, C Moermans, E Louis… - International journal of …, 2020 - mdpi.com
Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their
secretion within exosomes are a window that could further explain the regulation, the …

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

PF Sullivan, JRS Meadows, S Gazal, BDN Phan, X Li… - Science, 2023 - science.org
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Long non-coding RNAs in cardiac hypertrophy and heart failure: Functions, mechanisms and clinical prospects

JD Mably, DZ Wang - Nature Reviews Cardiology, 2024 - nature.com
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their
possible biological roles and effects on development and disease. ncRNAs have been …

Transcriptomic characterization of cow, donkey and goat milk extracellular vesicles reveals their anti-inflammatory and immunomodulatory potential

S Mecocci, D Pietrucci, M Milanesi, L Pascucci… - International journal of …, 2021 - mdpi.com
Milk extracellular vesicles (mEVs) seem to be one of the main maternal messages delivery
systems. Extracellular vesicles (EVs) are micro/nano-sized membrane-bound structures …

Evolution and function of developmentally dynamic pseudogenes in mammals

SH Qian, L Chen, YL Xiong, ZX Chen - Genome Biology, 2022 - Springer
Background Pseudogenes are excellent markers for genome evolution, which are emerging
as crucial regulators of development and disease, especially cancer. However, systematic …

[PDF][PDF] Evolution of gene expression across species and specialized zooids in Siphonophora

C Munro, F Zapata, M Howison… - … Biology and Evolution, 2022 - academic.oup.com
Siphonophores are complex colonial animals, consisting of asexually produced bodies
(zooids) that are functionally specialized for specific tasks, including feeding, swimming, and …

The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO‐Mediated Nuclear Export of ZEB1 mRNA

YR Hou, LT Diao, YX Hu, QQ Zhang, G Lv… - Advanced …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is an aggressive and fatal disease caused by a subset of
cancer stem cells (CSCs). It is estimated that there are approximately 100 000 long …

Transcriptomics of meiosis in the male mouse

A Geisinger, R Rodríguez-Casuriaga… - Frontiers in cell and …, 2021 - frontiersin.org
Molecular studies of meiosis in mammals have been long relegated due to some intrinsic
obstacles, namely the impossibility to reproduce the process in vitro, and the difficulty to …

LncRNAs in domesticated animals: from dog to livestock species

S Lagarrigue, M Lorthiois, F Degalez, D Gilot… - Mammalian …, 2022 - Springer
Animal genomes are pervasively transcribed into multiple RNA molecules, of which many
will not be translated into proteins. One major component of this transcribed non-coding …

GepLiver: an integrative liver expression atlas spanning developmental stages and liver disease phases

Z Li, H Zhang, Q Li, W Feng, X Jia, R Zhou, Y Huang… - Scientific Data, 2023 - nature.com
Chronic liver diseases usually developed through stepwise pathological transitions under
the persistent risk factors. The molecular changes during liver transitions are pivotal to …