There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic …
NPH Knudsen, A Olsen, C Buonsanti, F Follmann… - Scientific reports, 2016 - nature.com
The majority of vaccine candidates in clinical development are highly purified proteins and peptides relying on adjuvants to enhance and/or direct immune responses. Despite the …
SM Gheibi Hayat, M Darroudi - Journal of cellular physiology, 2019 - Wiley Online Library
Despite great advances in the field of vaccination, there are still needs for novel and effective vaccines because still no effective vaccines have been produced for some …
J Leleux, K Roy - Advanced healthcare materials, 2013 - Wiley Online Library
The development and widespread application of vaccines has been one of the most significant achievements of modern medicine. Vaccines have not only been instrumental in …
X Li, X Wang, A Ito - Chemical Society Reviews, 2018 - pubs.rsc.org
Vaccines, one of the most effective and powerful public health measures, have saved countless lives over the past century and still have a tremendous global impact. As an …
C Rueckert, CA Guzmán - PLoS pathogens, 2012 - journals.plos.org
Infectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant …
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the …
ME Gambuzza, V Sofo, FM Salmeri… - CNS & Neurological …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder mainly characterized by amyloid- β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic …
Differentiation of naïve B cells, including immunoglobulin class-switch DNA recombination, is critical for the immune response and depends on the extensive integration of signals from …