Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

Targeting Toll-like receptors: emerging therapeutics?

EJ Hennessy, AE Parker, LAJ O'neill - Nature reviews Drug discovery, 2010 - nature.com
There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention
and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic …

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

NPH Knudsen, A Olsen, C Buonsanti, F Follmann… - Scientific reports, 2016 - nature.com
The majority of vaccine candidates in clinical development are highly purified proteins and
peptides relying on adjuvants to enhance and/or direct immune responses. Despite the …

Nanovaccine: A novel approach in immunization

SM Gheibi Hayat, M Darroudi - Journal of cellular physiology, 2019 - Wiley Online Library
Despite great advances in the field of vaccination, there are still needs for novel and
effective vaccines because still no effective vaccines have been produced for some …

Micro and nanoparticle‐based delivery systems for vaccine immunotherapy: an immunological and materials perspective

J Leleux, K Roy - Advanced healthcare materials, 2013 - Wiley Online Library
The development and widespread application of vaccines has been one of the most
significant achievements of modern medicine. Vaccines have not only been instrumental in …

Tailoring inorganic nanoadjuvants towards next-generation vaccines

X Li, X Wang, A Ito - Chemical Society Reviews, 2018 - pubs.rsc.org
Vaccines, one of the most effective and powerful public health measures, have saved
countless lives over the past century and still have a tremendous global impact. As an …

Vaccines: from empirical development to rational design

C Rueckert, CA Guzmán - PLoS pathogens, 2012 - journals.plos.org
Infectious diseases are responsible for an overwhelming number of deaths worldwide and
their clinical management is often hampered by the emergence of multi-drug-resistant …

Zika virus structural biology and progress in vaccine development

HH Lin, BS Yip, LM Huang, SC Wu - Biotechnology advances, 2018 - Elsevier
The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal
microcephaly in newborns in Brazil have raised alarms in many countries regarding the …

Toll-like receptors in Alzheimer's disease: a therapeutic perspective

ME Gambuzza, V Sofo, FM Salmeri… - CNS & Neurological …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder mainly characterized by amyloid-
β (Aβ) plaques, neurofibrillary tangles, loss of synapses and neurons and chronic …

Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses

EJ Pone, H Zan, J Zhang, A Al-Qahtani… - Critical Reviews™ in …, 2010 - dl.begellhouse.com
Differentiation of naïve B cells, including immunoglobulin class-switch DNA recombination,
is critical for the immune response and depends on the extensive integration of signals from …