Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Domesticated plants have long served as excellent models for studying evolution. Many
genes and mutations underlying important domestication traits have been identified, and …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Plasmids are one of the most commonly used platforms for genetic engineering and
recombinant gene expression in bacteria. The range of available copy numbers for cloning …

The molecular alterations that occur in cells before cancer is manifest are largely uncharted.
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …

The replication of members of the two circular single-stranded DNA (ssDNA) virus families
Geminiviridae and Nanoviridae, the only ssDNA viruses infecting plants, is believed to be …

Quantitative real-time PCR (qPCR) has been widely used in recent environmental microbial
ecology studies as a tool for detecting and quantifying microorganisms of interest, which …

Objectives Tigecycline represents one of the last-line therapeutics to combat multidrug-
resistant bacterial pathogens, including VRE and MRSA. The German National Reference …

Multipartite viruses have one of the most puzzling genetic organizations found in living
organisms. These viruses have several genome segments, each containing only a part of …

Membrane transport proteins are potential targets for medical and biotechnological
applications. However, more than 30% of reported membrane transporter families are either …