Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

SI Grivennikov, M Karin - Annals of the rheumatic diseases, 2011 - ard.bmj.com
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

Human disorders associated with inflammation and the evolving role of natural products to overcome

N Kishore, P Kumar, K Shanker, AK Verma - European journal of medicinal …, 2019 - Elsevier
Inflammation is a biological function which triggered after the mechanical tissue disruption or
from the responses by the incidence of physical, chemical or biological negotiator in body …

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

I Lerner, E Hermano, E Zcharia… - The Journal of …, 2011 - Am Soc Clin Investig
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated
with colon cancer. Expression of the enzyme heparanase is clearly linked to colon …

Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility

Y Zhang, KK Do, F Wang, X Lu, JY Liu, C Li… - Communications …, 2023 - nature.com
The cornea is the outmost ocular tissue and plays an important role in protecting the eye
from environmental insults. Corneal epithelial wounding provokes pain and fear and …

Intestinal epithelial cell apoptosis and loss of barrier function in the setting of altered microbiota with enteral nutrient deprivation

FR Demehri, M Barrett, MW Ralls… - Frontiers in cellular …, 2013 - frontiersin.org
Total parenteral nutrition (TPN), a commonly used treatment for patients who cannot receive
enteral nutrition, is associated with significant septic complications due in part to a loss of …

Genomic imprinting in germ cells: imprints are under control

P Arnaud - Reproduction, 2010 - rep.bioscientifica.com
The activities of acid beta-glucuronidase, alpha-mannosidase, alpha-glucosidase, alpha-
galactosidase, beta-galactosidase and beta-N-acetylglucosaminidase were analysed in …

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33

MA Schumacher, JJ Hsieh, CY Liu, KL Appel… - Nature …, 2021 - nature.com
Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the
response to injury or inflammation. Sprouty2, an intracellular signaling regulator, controls …

[HTML][HTML] NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury

SS Seregin, N Golovchenko, B Schaf, J Chen… - Mucosal …, 2017 - Elsevier
NLRP6 is a member of the Nod-like receptor family, whose members are involved in the
recognition of microbes and/or tissue injury. NLRP6 was previously demonstrated to …

Anti-inflammatory phytochemicals for chemoprevention of colon cancer

V Madka, CV Rao - Current cancer drug targets, 2013 - ingentaconnect.com
Every year more than a million new cancer cases and 600,000 deaths are reported world-
wide. Colorectal cancer is the fourth most commonly occurring and second leading cause of …

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

PM Madsen, BH Clausen, M Degn… - Journal of Cerebral …, 2016 - journals.sagepub.com
Microglia respond to focal cerebral ischemia by increasing their production of the
neuromodulatory cytokine tumor necrosis factor, which exists both as membrane-anchored …