[PDF][PDF] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

[HTML][HTML] Translating phage therapy into the clinic: recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

[HTML][HTML] The safety and efficacy of phage therapy: a systematic review of clinical and safety trials

HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …

[HTML][HTML] The future of clinical phage therapy in the United Kingdom

JD Jones, C Trippett, M Suleman, MRJ Clokie, JR Clark - Viruses, 2023 - mdpi.com
Bacteriophage (phage) therapy is a promising alternative antimicrobial strategy with the
potential to transform the way bacterial infections are treated. In the United Kingdom, phages …

[HTML][HTML] Current clinical landscape and global potential of bacteriophage therapy

NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …

[HTML][HTML] Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention.

E Almanza-Aguilera, A Cano, M Gil-Lespinard… - Seminars in Cancer …, 2023 - Elsevier
Olive oil (OO) is the main source of added fat in the Mediterranean diet (MD). It is a mix of
bioactive compounds, including monounsaturated fatty acids, phytosterols, simple phenols …

A retrospective, observational study of 12 cases of expanded-access customized phage therapy: production, characteristics, and clinical outcomes

SI Green, JR Clark, HH Santos… - Clinical Infectious …, 2023 - academic.oup.com
Background Antimicrobial resistance (AMR) is undermining modern medicine, a problem
compounded by bacterial adaptation to antibiotic pressures. Phages are viruses that infect …

[HTML][HTML] The resurgence of phage-based therapy in the era of increasing antibiotic resistance: from research progress to challenges and prospects

NJ Anyaegbunam, CC Anekpo… - Microbiological …, 2022 - Elsevier
Phage therapy was implemented almost a century ago but was subsequently abandoned
when antibiotics emerged. However, the rapid emergence of drug-resistant, which has …

[HTML][HTML] Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections

MS Linz, A Mattappallil, D Finkel, D Parker - Antibiotics, 2023 - mdpi.com
The pathogenic bacterium Staphylococcus aureus is the most common pathogen isolated in
skin-and-soft-tissue infections (SSTIs) in the United States. Most S. aureus SSTIs are caused …