Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders.
We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Metformin induces modest weight loss in overweight and obese individuals at risk for
diabetes. A more detailed understanding of how metformin induces weight loss will likely …

In association with sleep–wake and fasting–feeding cycles, organisms experience dramatic
oscillations in energetic demands and nutrient supply. It is therefore not surprising that …

Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease,
including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia …

Circadian timekeeping systems drive oscillatory gene expression to regulate essential
cellular and physiological processes. When the systems are perturbed, pathological …

Fortunate are those who rise out of bed to greet the morning light well rested with the energy
and enthusiasm to drive a productive day. Others, however, depend on hypnotics for sleep …