The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation
HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?
AW Tong, J Nemunaitis - Cancer gene therapy, 2008 - nature.com
MicroRNAs (miRNAs) were discovered more than a decade ago as noncoding, single-
stranded small RNAs (∼ 22 nucleotides) that control the timed gene expression pattern in …
stranded small RNAs (∼ 22 nucleotides) that control the timed gene expression pattern in …
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
V Tarasov, P Jung, B Verdoodt, D Lodygin… - Cell cycle, 2007 - Taylor & Francis
In a genome‑wide screen for microRNAs regulated by the transcription factor encoded by
the p53 tumor suppressor gene we found that after p53‑activation the abundance of thirty …
the p53 tumor suppressor gene we found that after p53‑activation the abundance of thirty …
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
D Lodygin, V Tarasov, A Epanchintsev, C Berking… - Cell cycle, 2008 - Taylor & Francis
Recently, we and others identified the microRNA miR-34a as a target of the tumor
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
A Menssen, P Hydbring, K Kapelle… - Proceedings of the …, 2012 - National Acad Sciences
Silent information regulator 1 (SIRT1) represents an NAD+-dependent deacetylase that
inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is …
inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is …
Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
M Kaller, ST Liffers, S Oeljeklaus, K Kuhlmann… - Molecular & Cellular …, 2011 - ASBMB
The gene encoding the miR-34a microRNA is a transcriptional target of the p53 tumor
suppressor protein and subject to epigenetic inactivation in colorectal cancer and numerous …
suppressor protein and subject to epigenetic inactivation in colorectal cancer and numerous …
Therapeutic microRNA strategies in human cancer
Abstract MicroRNAs (miRNAs) are~ 22 nucleotide long, noncoding, endogenous RNA
molecules which exert their functions by base pairing with messenger RNAs (mRNAs) …
molecules which exert their functions by base pairing with messenger RNAs (mRNAs) …
AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer
The basic helix-loop-helix transcription factor AP4/TFAP4/AP-4 is encoded by a c-MYC
target gene and displays up-regulation concomitantly with c-MYC in colorectal cancer (CRC) …
target gene and displays up-regulation concomitantly with c-MYC in colorectal cancer (CRC) …
Expression patterns of microRNAs associated with CML phases and their disease related targets
K Machová Poláková, T Lopotová, H Klamová, P Burda… - Molecular cancer, 2011 - Springer
Background MicroRNAs are important regulators of transcription in hematopoiesis. Their
expression deregulations were described in association with pathogenesis of some …
expression deregulations were described in association with pathogenesis of some …
Tetracycline‐inducible expression systems: new strategies and practices in the transgenic mouse modeling
Y Sun, X Chen, D Xiao - Acta biochimica et biophysica Sinica, 2007 - Wiley Online Library
To accurately analyze the function of transgene (s) of interest in transgenic mice, and to
generate credible transgenic animal models for multifarious human diseases to precisely …
generate credible transgenic animal models for multifarious human diseases to precisely …