Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Despite considerable efforts, malaria is still one of the most devastating infectious diseases
in the tropics. The rapid spread of antimalarial drug resistance currently compounds this …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance,. Here …

Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in
malaria mortality and morbidity. Recent laboratory and clinical studies have associated …

The tempo and mode of adaptive evolution determine how natural selection shapes patterns
of genetic diversity in DNA polymorphism data. While slow mutation‐limited adaptation …

Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …

Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the
digestive vacuole transmembrane protein PfCRT. However, the contribution of individual …

Recent studies have highlighted the importance of a parasite protein referred to as the
chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum …

Chloroquine resistance in Plasmodium falciparum is primarily conferred by mutations in
pfcrt. Parasites resistant to chloroquine can display hypersensitivity to other antimalarials; …

Abstract Papua New Guinea (PNG) is a patchwork of different ecological zones, inhabited by
human populations of exceptional cultural and linguistic diversity. This results in complex …