Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell …
The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to …
Stress-induced Epstein-Barr virus reactivation
DG Sausen, MS Bhutta, ES Gallo, H Dahari… - Biomolecules, 2021 - mdpi.com
Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in
immunocompetent individuals. Perturbations of the host immune system can stimulate viral …
immunocompetent individuals. Perturbations of the host immune system can stimulate viral …
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …
MYC multimers shield stalled replication forks from RNA polymerase
D Solvie, A Baluapuri, L Uhl, D Fleischhauer, T Endres… - Nature, 2022 - nature.com
Oncoproteins of the MYC family drive the development of numerous human tumours. In
unperturbed cells, MYC proteins bind to nearly all active promoters and control transcription …
unperturbed cells, MYC proteins bind to nearly all active promoters and control transcription …
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes
SETD2 is a histone H3 lysine 36 (H3K36) trimethyltransferase that is mutated with high
prevalence (13%) in clear cell renal cell carcinoma (ccRCC). Genomic profiling of primary …
prevalence (13%) in clear cell renal cell carcinoma (ccRCC). Genomic profiling of primary …
Structure and function of the histone chaperone FACT–Resolving FACTual issues
Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …
transcription through chromatin mostly based on cell-free experiments. However, FACT …
[HTML][HTML] Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory
X Yuan, JA Seneviratne, S Du, Y Xu, Y Chen, Q Jin… - Cell Reports, 2022 - cell.com
Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors,
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …
Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma
Amplification of the MYCN oncogene is associated with an aggressive phenotype and poor
outcome in childhood neuroblastoma. Polyamines are highly regulated essential cations …
outcome in childhood neuroblastoma. Polyamines are highly regulated essential cations …
An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
Z Nagy, JA Seneviratne, M Kanikevich… - Nature …, 2021 - nature.com
To achieve the very high oncoprotein levels required to drive the malignant state cancer
cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here …
cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here …
MYC controls the Epstein-Barr virus lytic switch
Epstein-Barr virus (EBV) is associated with multiple human malignancies. To evade immune
detection, EBV switches between latent and lytic programs. How viral latency is maintained …
detection, EBV switches between latent and lytic programs. How viral latency is maintained …