Abstract Dapsone (4, 4′-diaminodiphenylsulfone) is an aniline derivative belonging to the
group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial …

In their 60-year history, dapsone and the sulfones have been used as both antibacterial and
anti-inflammatory agents. Dapsone has been used successfully to treat a range of …

Dapsone is useful in the treatment of a number of inflammatory conditions which are
characterized by neutrophil infiltration. It is the drug of choice for suppression of the …

The human cytochrome P450 enzyme system metabolises a wide array of xenobiotics to
pharmacologically inactive metabolites, and occasionally, to toxicologically active …

Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …

Since its introduction in 1987, zidovudine monotherapy has been the treatment of choice for
patients with HIV infection. Unfortunately it has been established that the beneficial effects of …

1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in
six dermatitis herpetiformis patients stabilised on dapsone by the co‐administration of …

Combination of antimalarial agents has been introduced as a response to widespread drug
resistance. The higher number of mutations required to express complete resistance against …

Adverse drug reactions can be caused by the parent drug or a metabolite of that drug. The
metabolite may be stable or chemically reactive, the resultant toxicity being either a direct …

Dapsone is a chemotherapeutic agent primarily used in treating leprosy, Pneumocystis
jiroveci (previously carinii) pneumonia, and malaria. It is also used as an adjuvant in the …