In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …

RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

Background Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can
bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby …

Some long noncoding RNAs (lncRNAs) play important roles in the regulation of gene
expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of …

Considering the high mortality rate encountered in lung cancer, there is a strong need to
explore new biomarkers for early diagnosis and also improved therapeutic targets to …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

MiR-145 can regulate cell apoptosis, proliferation, neural development and stem cell
differentiation. Previous studies indicate that miR-145 is downregulated in human colon …

Tumor dissemination and metastatic behavior account for the vast majority of cancer
associated mortality. Epithelial tumors achieve this progressive state via epithelial-to …

Exosomal microRNA (miRNA) secretion has been characterized as a vital factor in
intercellular communication among cancer cells. However, little is known about cancer …