The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Sepsis-induced cardiomyopathy (SICM) is common in septic patients with a high mortality
and is characterized by an abnormal immune response. Owing to cellular heterogeneity …

Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …

Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a
pivotal role in cell homeostasis, but its contribution to macrophage functions and host …

Mitochondrial quality control is central for maintaining a healthy population of mitochondria.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …

Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Mitochondrial quality is a crucial determinant of cell viability, and mitochondrial autophagy
plays a central role in this control mechanism. Based on studies in yeast, numerous …

Sepsis-associated encephalopathy (SAE) manifested clinically in acute and long-term
cognitive impairments and associated with increased morbidity and mortality worldwide. The …