The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

BG Dogaru, C Munteanu - International Journal of Molecular Sciences, 2023 - mdpi.com
This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …

Epidrugs in the therapy of central nervous system disorders: a way to drive on?

MG Gladkova, E Leidmaa, EA Anderzhanova - Cells, 2023 - mdpi.com
The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …

Quantitative estimate of cognitive resilience and its medical and genetic associations

T Phongpreecha, D Godrich, E Berson… - Alzheimer's research & …, 2023 - Springer
Background We have proposed that cognitive resilience (CR) counteracts brain damage
from Alzheimer's disease (AD) or AD-related dementias such that older individuals who …

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

YA Kim, M Mellen, C Kizil… - British Journal of …, 2024 - Wiley Online Library
Intracellular accumulation of hyperphosphorylated misfolded tau proteins are found in many
neurodegenerative tauopathies, including Alzheimer's disease (AD). Tau pathology can …

The major hypotheses of Alzheimer's disease: related nanotechnology-based approaches for its diagnosis and treatment

C Cáceres, B Heusser, A Garnham, E Moczko - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is a well-known chronic neurodegenerative disorder that leads to
the progressive death of brain cells, resulting in memory loss and the loss of other critical …

The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms

S Giallongo, F Costa, L Longhitano, C Giallongo… - Metabolites, 2023 - mdpi.com
Tumor onset and its progression are strictly linked to its metabolic rewiring on the basis of
the Warburg effect. In this context, fumarate emerged as a putative oncometabolite …

Exploring the genetic predisposition to epigenetic changes in Alzheimer's disease

LO Bryzgalov, EE Korbolina, TI Merkulova - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a
significant genetic component. The accumulating evidence suggests that AD involves a …

Epigenetic Mechanisms in Inflammation

R Dahiya, R Thapa, NK Kumawat, M Singh… - Targeting Epigenetics in …, 2023 - Springer
Epigenetic modifications are triggered by environmental changes and play a critical role in
how genes are expressed in response to stimuli. The common epigenetic processes include …

Mesenchymal stromal cells in tumor microenvironment remodeling of BCR-ABL negative myeloproliferative diseases

E La Spina, S Giallongo, C Giallongo, N Vicario… - Frontiers in …, 2023 - frontiersin.org
Chronic myeloproliferative neoplasms encompass the BCR-ABL1-negative neoplasms
polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) …

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

A Warren, Y Nyavor, N Zarabian, A Mahoney… - Frontiers in …, 2024 - frontiersin.org
Importance Research is beginning to elucidate the sophisticated mechanisms underlying
the microbiota-gut-brain-immune interface, moving from primarily animal models to human …