Cancer is an epigenetic disease at the same level that it can be considered a genetic
disease. In fact, epigenetic changes, particularly DNA methylation, are susceptible to …

Pre-mRNA splicing is a sophisticated and ubiquitous nuclear process, which is a natural
source of cancer-causing errors in gene expression. Intronic splice site mutations of tumor …

Ferroptosis is primarily caused by intracellular iron catalytic activity and lipid peroxidation.
The potential interplay between ferroptosis and apoptosis remains poorly understood. Here …

Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl
(fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

Changes in DNA methylation patterns are an important characteristic of human cancer.
Tumors have reduced levels of genomic DNA methylation and contain hypermethylated …

Cancer is nowadays recognised as a genetic and epigenetic disease. Much effort has been
devoted in the last 30 years to the elucidation of the 'classical'oncogenes and tumour …

Monitoring human antibody recognition of tumor antigens could have potential diagnostic
and prognosticsignificance. Serological analysis of recombinant cDNA expression libraries …

Background Cancer associated with smoking and drinking remains a serious health
problem worldwide. The survival of patients is very poor due to the lack of effective early …

Imperfect maintenance of genome integrity has been postulated to be an important cause of
aging. Here we provide support for this hypothesis by demonstrating that the disruption of …