Viral tropism is the ability of viruses to enter and infect specific host cells and is based on the
ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended …

Given the extreme variability of the human immunodeficiency virus (HIV) and its ability to
replicate as complex viral populations, HIV variants with reduced susceptibility to …

HIV-1 coreceptor tropism assays are required to rule out the presence of CXCR4-tropic (non-
R5) viruses prior treatment with CCR5 antagonists. Phenotypic (eg, Trofile™, Monogram …

With 29 individual antiretroviral drugs available from six classes that are approved for the
treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is …

Objective: Cysteine-cysteine receptor 5 (CCR5)-using viruses classically predominate
during HIV-1 primary infection but the frequency of cysteine-X-cysteine receptor 4 (CXCR4) …

CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse
conformations and oligomerization states. We interrogated the significance of the CCR5 …

Genotypic algorithms for prediction of HIV-1 coreceptor usage need to be evaluated in a
clinical setting. We aimed at studying (i) the correlation of genotypic prediction of coreceptor …

Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-
1 infected individuals, yet achieving better access to vulnerable populations remains a …

Objective: The theory that a more thinly keratinized inner foreskin leads to increased HIV-1
susceptibility has been based on relatively little published data. We sought to quantify the …

The approval of maraviroc (Selzentri®), the first CCR5 antagonist, with specific antiviral
activity against CCR5 (R5)-tropic HIV variants, has promoted the determination of HIV …