Cachexia: A systemic consequence of progressive, unresolved disease

M Ferrer, TG Anthony, JS Ayres, G Biffi, JC Brown… - Cell, 2023 - cell.com
Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

Muscle metabolism and atrophy: let's talk about sex

ME Rosa-Caldwell, NP Greene - Biology of sex differences, 2019 - Springer
Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies
affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular …

Cancer cachexia: more than skeletal muscle wasting

SF Schmidt, M Rohm, S Herzig, MB Diaz - Trends in cancer, 2018 - cell.com
Cancer cachexia is a multifactorial condition characterized by body weight loss that
negatively affects quality of life and survival of patients with cancer. Despite the clinical …

STAT3 in the systemic inflammation of cancer cachexia

TA Zimmers, ML Fishel, A Bonetto - Seminars in cell & developmental …, 2016 - Elsevier
Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Role of interleukin-6 in cachexia: therapeutic implications

AA Narsale, JA Carson - … opinion in supportive and palliative care, 2014 - journals.lww.com
IL-6 remains a promising therapeutic strategy for attenuating cachexia progression with
many types of cancer. However, improvement of this treatment will require a better …

Physical activity as the best supportive care in cancer: the clinician's and the researcher's perspectives

C Torregrosa, F Chorin, EEM Beltran, C Neuzillet… - Cancers, 2022 - mdpi.com
Simple Summary This literature review on adapted physical exercise has been written in
order to raise awareness of medical staff to this central theme in the management of cancer …

The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting

JA Carson, JP Hardee, BN VanderVeen - Seminars in cell & developmental …, 2016 - Elsevier
While skeletal muscle mass is an established primary outcome related to understanding
cancer cachexia mechanisms, considerable gaps exist in our understanding of muscle …

Androgen-mediated regulation of skeletal muscle protein balance

ML Rossetti, JL Steiner, BS Gordon - Molecular and cellular endocrinology, 2017 - Elsevier
Androgens significantly alter muscle mass in part by shifting protein balance in favor of net
protein accretion. During various atrophic conditions, the clinical impact of decreased …

Understanding the role of exercise in cancer cachexia therapy

JP Hardee, BR Counts… - American journal of …, 2019 - journals.sagepub.com
Cachexia, the unintentional loss of body weight, is prevalent in many cancer types, and the
associated skeletal muscle mass depletion increases patient morbidity and mortality. While …

Systemic inflammation in cachexia–is tumor cytokine expression profile the culprit?

EM de Matos-Neto, JDCC Lima… - Frontiers in …, 2015 - frontiersin.org
Cachexia affects about 80% of gastrointestinal cancer patients. This multifactorial syndrome
resulting in involuntary and continuous weight loss is accompanied by systemic …