Methods and applications for single-cell and spatial multi-omics
K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …
from single cells is transforming our understanding of cell biology in health and disease. In …
Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin
Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment.
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …
The role of myofibroblasts in physiological and pathological tissue repair
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …
[HTML][HTML] Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing
Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …
[HTML][HTML] Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer
Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …
Construction of a 3D whole organism spatial atlas by joint modelling of multiple slices with deep neural networks
Spatial transcriptomics (ST) technologies are revolutionizing the way to explore the spatial
architecture of tissues. Currently, ST data analysis is often restricted to a single two …
architecture of tissues. Currently, ST data analysis is often restricted to a single two …
Deciphering tissue structure and function using spatial transcriptomics
The rapid development of spatial transcriptomics (ST) techniques has allowed the
measurement of transcriptional levels across many genes together with the spatial positions …
measurement of transcriptional levels across many genes together with the spatial positions …
Spatial omics: Navigating to the golden era of cancer research
Y Wu, Y Cheng, X Wang, J Fan… - Clinical and Translational …, 2022 - Wiley Online Library
The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …
surprise many cancer biologists; however, systematically capturing spatial architecture of …