Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic
wounds, and macrophage malfunction is considered as a major contributor thereof. In this …

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

Recent findings have demonstrated that mitochondria can be transferred between cells to
control metabolic homeostasis. Although the mitochondria of brown adipocytes comprise a …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

Microglia M1 phenotype causes HPA axis hyperactivity, neurotransmitter dysfunction, and
production of proinflammatory mediators and oxidants, which may contribute to the etiology …

Retinoic acid–related orphan receptor α (RORα) is considered a key regulator of
polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis …

Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that
primarily affects women. Currently, in the search for the mechanisms of SLE pathogenesis …