Current cancer immunotherapies are primarily predicated on αβ T cells, with a stringent
dependence on MHC-mediated presentation of tumour-enriched peptides or unique …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Clinical responses to checkpoint inhibitors used for cancer immunotherapy seemingly
require the presence of αβT cells that recognize tumour neoantigens, and are therefore …

T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …

Shortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17
cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory …

The unique features of gamma-delta (γδ) T cells, related to their antigen recognition
capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates …