Resolution of inflammation: what controls its onset?
An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …
acute inflammation to persistent chronic inflammation. It has now become evident that …
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
KT Liby, MB Sporn - Pharmacological reviews, 2012 - ASPET
We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …
and treatment of disease, as well as extensive biological data on this topic resulting from …
Resolution of inflammation in bone regeneration: From understandings to therapeutic applications
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …
economic and clinical impact. While an inflammatory response upon injury is necessary to …
Lipid metabolism in inflammation-related diseases
C Zhang, K Wang, L Yang, R Liu, Y Chu, X Qin, P Yang… - Analyst, 2018 - pubs.rsc.org
There are thousands of lipid species existing in cells, which belong to eight different
categories. Lipids are the essential building blocks of cells. Recent studies have started to …
categories. Lipids are the essential building blocks of cells. Recent studies have started to …
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles
Cells produce electrophilic products with the potential to modify and affect the function of
proteins. Chemoproteomic methods have provided a means to qualitatively inventory …
proteins. Chemoproteomic methods have provided a means to qualitatively inventory …
Resolution of inflammation: mechanisms and opportunity for drug development
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections
AEF Sheppe, MJ Edelmann - Infection and Immunity, 2021 - Am Soc Microbiol
Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
Prostanoids and resolution of inflammation–beyond the lipid-mediator class switch
T Schmid, B Brüne - Frontiers in immunology, 2021 - frontiersin.org
Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein,
early pro-inflammatory phases are characterized and regulated by prostanoids and …
early pro-inflammatory phases are characterized and regulated by prostanoids and …
Endogenous cannabinoids revisited: a biochemistry perspective
BM Fonseca, MA Costa, M Almada… - Prostaglandins & other …, 2013 - Elsevier
Marijuana is the most commonly used illegal drug, particularly in Western societies. The
discovery of an endogenous cannabinoid system (ECS) highlighted new molecules in …
discovery of an endogenous cannabinoid system (ECS) highlighted new molecules in …
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease
I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …