Resolution of inflammation: what controls its onset?

MA Sugimoto, LP Sousa, V Pinho, M Perretti… - Frontiers in …, 2016 - frontiersin.org
An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease

KT Liby, MB Sporn - Pharmacological reviews, 2012 - ASPET
We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

H Newman, YV Shih, S Varghese - Biomaterials, 2021 - Elsevier
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Lipid metabolism in inflammation-related diseases

C Zhang, K Wang, L Yang, R Liu, Y Chu, X Qin, P Yang… - Analyst, 2018 - pubs.rsc.org
There are thousands of lipid species existing in cells, which belong to eight different
categories. Lipids are the essential building blocks of cells. Recent studies have started to …

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

C Wang, E Weerapana, MM Blewett, BF Cravatt - Nature methods, 2014 - nature.com
Cells produce electrophilic products with the potential to modify and affect the function of
proteins. Chemoproteomic methods have provided a means to qualitatively inventory …

Resolution of inflammation: mechanisms and opportunity for drug development

AL Alessandri, LP Sousa, CD Lucas, AG Rossi… - Pharmacology & …, 2013 - Elsevier
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections

AEF Sheppe, MJ Edelmann - Infection and Immunity, 2021 - Am Soc Microbiol
Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …

Prostanoids and resolution of inflammation–beyond the lipid-mediator class switch

T Schmid, B Brüne - Frontiers in immunology, 2021 - frontiersin.org
Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein,
early pro-inflammatory phases are characterized and regulated by prostanoids and …

Endogenous cannabinoids revisited: a biochemistry perspective

BM Fonseca, MA Costa, M Almada… - Prostaglandins & other …, 2013 - Elsevier
Marijuana is the most commonly used illegal drug, particularly in Western societies. The
discovery of an endogenous cannabinoid system (ECS) highlighted new molecules in …

The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease

I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …