Mucins as potential biomarkers for early detection of cancer

SK Gautam, P Khan, G Natarajan, P Atri, A Aithal… - Cancers, 2023 - mdpi.com
Simple Summary Early cancer detection is a challenge in treating cancer patients.
Remarkably, carcinomas of the breast, lung, liver, pancreas, ovary, and colon contribute to …

LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein

Y Liang, X Chen, Y Wu, J Li, S Zhang, K Wang… - Cell Death & …, 2018 - nature.com
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer.
Long noncoding RNAs (lncRNAs) are thought to play a critical role in cancer development …

Prognostic value of blood-based protein biomarkers in non-small cell lung cancer: A critical review and 2008–2022 update

I Trulson, S Holdenrieder - Tumor Biology, 2024 - journals.sagepub.com
BACKGROUND: Therapeutic possibilities for non-small cell lung cancer (NSCLC) have
considerably increased during recent decades. OBJECTIVE: To summarize the prognostic …

Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K …

L Qiu, J Wang, M Chen, F Chen… - … journal of molecular …, 2020 - spandidos-publications.com
The carrier role of exosomes from human umbilical cord mesenchymal stem cells
(hUCMSCs) containing microRNAs (miRNAs) has been implicated in gene and drug …

[HTML][HTML] LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral

F Shan, L Liang, C Feng, H Xu, Z Wang, W Liu… - Oncology …, 2023 - ncbi.nlm.nih.gov
Background Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently,
Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; …

Laminins and cancer stem cells: Partners in crime?

Y Qin, S Rodin, OE Simonson, F Hollande - Seminars in cancer biology, 2017 - Elsevier
As one of the predominant protein families within the extracellular matrix both structurally
and functionally, laminins have been shown to be heavily involved in tumor progression and …

Extracellular matrix functions in lung cancer

M Götte, I Kovalszky - Matrix Biology, 2018 - Elsevier
Lung cancer is one of the most devastating types of malignant tumors, and a prime example
of a chemical carcinogenesis-driven tumor entity. Lung cancer progression does not only …

[HTML][HTML] High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma

MA Hoda, A Rozsas, E Lang, T Klikovits, Z Lohinai… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in
different tumor types including lung adenocarcinoma (LADC). Here, we report that serum …

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses

GR You, AJ Cheng, LY Lee, YC Huang, H Liu, YJ Chen… - BMC cancer, 2019 - Springer
Background Radiotherapy is an indispensable treatment modality in head and neck cancer
(HNC), while radioresistance is the major cause of treatment failure. The aim of this study is …

Overexpressed LAMC2 promotes trophoblast over‐invasion through the PI3K/Akt/MMP2/9 pathway in placenta accreta spectrum

R Wang, W Liu, J Zhao, L Liu, S Li… - Journal of Obstetrics …, 2023 - Wiley Online Library
Background Placenta accreta spectrum (PAS) is an ongoing major iatrogenic public health
challenge with devastating obstetric complications, but its underlying molecular …