Scanning probe microscopy

K Bian, C Gerber, AJ Heinrich, DJ Müller… - Nature Reviews …, 2021 - nature.com
Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …

Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021 - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

[HTML][HTML] N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - elife, 2021 - elifesciences.org
SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …

Imaging modes of atomic force microscopy for application in molecular and cell biology

YF Dufrêne, T Ando, R Garcia, D Alsteens… - Nature …, 2017 - nature.com
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows
biological samples, from single molecules to living cells, to be visualized and manipulated …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Mechanomicrobiology: how bacteria sense and respond to forces

YF Dufrêne, A Persat - Nature Reviews Microbiology, 2020 - nature.com
Microorganisms have evolved to thrive in virtually any terrestrial and marine environment,
exposing them to various mechanical cues mainly generated by fluid flow and pressure as …

Electron microscopy of specimens in liquid

N De Jonge, FM Ross - Nature nanotechnology, 2011 - nature.com
Imaging samples in liquids with electron microscopy can provide unique insights into
biological systems, such as cells containing labelled proteins, and into processes of …

Direct evidence for the polymeric nature of polydopamine

P Delparastan, KG Malollari, H Lee… - Angewandte …, 2019 - Wiley Online Library
Inspired by the adhesive proteins of mussels, polydopamine (pDA) has emerged as one of
the most widely employed materials for surface functionalization. Despite numerous …

Multiparametric imaging of biological systems by force-distance curve–based AFM

YF Dufrêne, D Martínez-Martín, I Medalsy, D Alsteens… - Nature …, 2013 - nature.com
A current challenge in the life sciences is to understand how biological systems change their
structural, biophysical and chemical properties to adjust functionality. Addressing this issue …

[HTML][HTML] Application of atomic force microscopy in cancer research

X Deng, F Xiong, X Li, B Xiang, Z Li, X Wu… - Journal of …, 2018 - Springer
Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …