The epidemiology of Parkinson's disease: risk factors and prevention

A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of developing Parkinson's disease. Increased risk of …

Long-term health consequences of premature or early menopause and considerations for management

SS Faubion, CL Kuhle, LT Shuster, WA Rocca - Climacteric, 2015 - Taylor & Francis
Aim To review the current evidence concerning the long-term harmful effects of premature or
early menopause, and to discuss some of the clinical implications. Material and methods …

Incidence of Parkinson disease in North America

AW Willis, E Roberts, JC Beck, B Fiske, W Ross… - npj Parkinson's …, 2022 - nature.com
Parkinson disease (PD) is the second most common age-related neurodegenerative
condition diagnosed in North America. We recently demonstrated, using multiple …

ESHRE Guideline: management of women with premature ovarian insufficiency

Eshre Guideline Group on POI, L Webber… - Human …, 2016 - academic.oup.com
STUDY QUESTION What is the optimal management of women with premature ovarian
insufficiency (POI) based on the best available evidence in the literature? SUMMARY …

Estrogens, neuroinflammation, and neurodegeneration

A Villa, E Vegeto, A Poletti, A Maggi - Endocrine reviews, 2016 - academic.oup.com
Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

[HTML][HTML] Role of estrogen and other sex hormones in brain aging. Neuroprotection and DNA repair

S Zárate, T Stevnsner, R Gredilla - Frontiers in aging neuroscience, 2017 - frontiersin.org
Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Epidemiology and etiology of Parkinson's disease: a review of the evidence

K Wirdefeldt, HO Adami, P Cole, D Trichopoulos… - European journal of …, 2011 - Springer
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

[HTML][HTML] Neurosteroids as regulators of neuroinflammation

C Yilmaz, K Karali, G Fodelianaki, A Gravanis… - Frontiers in …, 2019 - Elsevier
Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality

SM Domchek, TM Friebel, CF Singer, DG Evans… - Jama, 2010 - jamanetwork.com
Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …

[HTML][HTML] Sex differences in Parkinson's disease

GE Gillies, IS Pienaar, S Vohra, Z Qamhawi - Frontiers in …, 2014 - Elsevier
Parkinson's disease (PD) displays a greater prevalence and earlier age at onset in men.
This review addresses the concept that sex differences in PD are determined, largely, by …