Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

Protein kinase C as a stress sensor

ME Barnett, DK Madgwick, DJ Takemoto - Cellular signalling, 2007 - Elsevier
While there are many reviews which examine the group of proteins known as protein kinase
C (PKC), the focus of this article is to examine the cellular roles of two PKCs that are …

Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat …

S Phalitakul, M Okada, Y Hara, H Yamawaki - Pharmacological Research, 2011 - Elsevier
Vaspin (visceral adipose tissue-derived serine protease inhibitor) was recently identified as
a novel adipocytokine with insulin-sensitizing effects. We hypothesized that vaspin could …

High fat diet‐induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

D Yu, G Chen, M Pan, J Zhang, W He… - Journal of cellular …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
with manifestation of over‐accumulation of fat in liver. Increasing evidences indicate that …

Protein kinase C-ε regulates the apoptosis and survival of glioma cells

H Okhrimenko, W Lu, C Xiang, N Hamburger… - Cancer research, 2005 - AACR
In this study, we examined the role of protein kinase C (PKC)-ε in the apoptosis and survival
of glioma cells using tumor necrosis factor–related apoptosis inducing ligand (TRAIL) …

Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways

P Su, J Zhang, S Wang, M Aschner, Z Cao, F Zhao… - Neurotoxicology, 2016 - Elsevier
Lead (Pb) is a ubiquitous environmental and industrial pollutant. It induces neurotoxicity and
cell death by disrupting the pro-and anti-oxidative balance; however, the mechanisms of its …

Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC‐ε Inactivation/ERK1/2 Activation

BK Lee, YS Jung - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Oxidative stress plays an important role in the pathophysiology of various neurologic
disorders. Allium cepa extract (ACE) and their main flavonoid component quercetin (QCT) …

Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics

MK Sun, DL Alkon - Pharmacology & therapeutics, 2010 - Elsevier
Evidence is accumulating indicating that some protein kinase C (PKC) isozymes play an
essential role in various phases as well as types of learning and memory. Abnormal …

Oxalate-induced activation of PKC-α and-δ regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells

V Thamilselvan, M Menon… - American Journal of …, 2009 - journals.physiology.org
Oxalate-induced oxidative stress contributes to cell injury and promotes renal deposition of
calcium oxalate crystals. However, we do not know how oxalate stimulates reactive oxygen …

Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCε

AMN Kabir, JE Clark, M Tanno, X Cao… - American Journal …, 2006 - journals.physiology.org
To examine whether cardioprotection initiated by reactive oxygen species (ROS) is
dependent on protein kinase Cε (PKCε), isolated buffer-perfused mouse hearts were …