miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

Inflammation originating from the adipose tissue is considered to be one of the main driving
forces for the development of insulin resistance and type 2 diabetes in obese individuals …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …

The contribution of cellular heterogeneity and architecture to white adipose tissue (WAT)
function is poorly understood. Herein, we combined spatially resolved transcriptional …

Adipose tissue is a major site of energy storage and has a role in the regulation of
metabolism through the release of adipokines. Here we show that mice with an adipose …

The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …

Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Triglyceride (TG) storage in adipose tissue provides the major reservoir for metabolic energy
in mammals. During lipolysis, fatty acids (FAs) are hydrolyzed from adipocyte TG stores and …

Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …

Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …